Jeffrey M Witkin Selected Research

Biological Products

1/2020	Imidazodiazepine Anticonvulsant, KRM-II-81, Produces Novel, Non-diazepam-like Antiseizure Effects.
4/2014	Discovery of a novel series of orally active nociceptin/orphanin FQ (NOP) receptor antagonists based on a dihydrospiro(piperidine-4,7'-thieno[2,3-c]pyran) scaffold.
6/2013	Curcumin, an active constiuent of the ancient medicinal herb Curcuma longa L.: some uses and the establishment and biological basis of medical efficacy.
6/2007	Constitutive deletion of the serotonin-7 (5-HT(7)) receptor decreases electrical and chemical seizure thresholds.

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Jeffrey M Witkin Research Topics

Disease

14	Seizures (Absence Seizure) 04/2022 - 09/2002
9	Epilepsy (Aura) 01/2022 - 06/2007
8	Major Depressive Disorder (Major Depressive Disorders) 01/2019 - 12/2005
7	Mental Disorders (Mental Disorder) 01/2021 - 08/2003
7	Mood Disorders (Mood Disorder) 01/2020 - 12/2005
5	Schizophrenia (Dementia Praecox) 01/2019 - 05/2006
4	Chronic Pain 01/2022 - 12/2016
4	Substance-Related Disorders (Drug Abuse) 01/2021 - 12/2005
4	Obesity 02/2016 - 12/2005
3	Post-Traumatic Epilepsy (Epilepsy, Post Traumatic) 01/2022 - 01/2020
3	Pain (Aches) 01/2019 - 06/2007
3	Shock 01/2019 - 10/2002
3	Alcoholism (Alcohol Abuse) 01/2019 - 03/2014
3	Parkinson Disease (Parkinson's Disease) 09/2011 - 05/2006
2	Postpartum Depression (Post-Natal Depression) 01/2022 - 01/2022
2	Neuralgia (Stump Neuralgia) 01/2022 - 12/2016
2	Treatment-Resistant Depressive Disorder 01/2021 - 10/2020
2	Psychotic Disorders (Schizoaffective Disorder) 01/2019 - 02/2003
2	Obsessive-Compulsive Disorder (Disorder, Obsessive-Compulsive) 01/2017 - 03/2006
2	Inflammation (Inflammations) 12/2016 - 06/2013
2	Hyperphagia (Overeating) 02/2016 - 01/2016
2	Body Weight (Weight, Body) 02/2016 - 03/2014
2	Anxiety Disorders (Anxiety Disorder) 06/2007 - 04/2006
1	Brain Injuries (Brain Injury) 01/2022
1	Respiratory Insufficiency (Respiratory Failure) 01/2022
1	Ataxia (Dyssynergia) 01/2022
1	Tremor (Tremors) 01/2022
1	Drug Resistant Epilepsy 01/2022
1	Tinnitus 01/2022
1	Status Epilepticus (Complex Partial Status Epilepticus) 01/2022
1	Traumatic Brain Injuries (Traumatic Brain Injury) 01/2020
1	Mania (Manias) 01/2020
1	Anhedonia 01/2019
1	Hyperalgesia 01/2019
1	Hypothermia 01/2019
1	Fatigue 01/2019
1	Nervous System Diseases (Neurological Disorders) 01/2018
1	Hypokinesia (Bradykinesia) 01/2018
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2018
1	Dementia (Dementias) 01/2018

Drug/Important Bio-Agent (IBA)

14	Antidepressive Agents (Antidepressants)IBA 01/2020 - 12/2005
7	Pentylenetetrazole (Metrazol)IBA 04/2022 - 09/2002
7	Cocaine (Cocaine HCl)IBA 08/2008 - 09/2002
6	N-Methylaspartate (NMDA)IBA 01/2021 - 09/2002
6	Anticonvulsants (Antiepileptic Drugs)IBA 01/2020 - 08/2003
6	Glutamic Acid (Glutamate)FDA Link 01/2019 - 07/2007
6	AMPA Receptors (AMPA Receptor)IBA 01/2019 - 04/2006
5	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 01/2021 - 04/2006
5	Proteins (Proteins, Gene)FDA Link 01/2019 - 01/2017
5	Pharmaceutical PreparationsIBA 01/2019 - 03/2014
4	KRM-II-81IBA 04/2022 - 01/2020
4	gamma-Aminobutyric Acid (GABA)IBA 01/2022 - 08/2003
4	Biological ProductsIBA 01/2020 - 06/2007
4	Anti-Anxiety Agents (Anxiolytics)IBA 01/2019 - 03/2006
4	LY3130481IBA 01/2019 - 01/2017
4	LY2940094IBA 01/2019 - 01/2016
4	TARPIBA 01/2019 - 01/2017
3	Aminobutyrates (Aminobutyric Acid)IBA 01/2022 - 01/2022
3	NeurosteroidsIBA 01/2022 - 08/2003
3	Ketamine FDA LinkGeneric 01/2021 - 01/2017
3	Dopamine (Intropin)FDA LinkGeneric 01/2018 - 02/2003
3	ConvulsantsIBA 01/2018 - 03/2007
3	NociceptinIBA 01/2016 - 03/2014
2	EsketamineIBA 01/2021 - 10/2020
2	Selective Serotonin Reuptake Inhibitors (Serotonin Reuptake Inhibitors)IBA 01/2020 - 01/2017
2	Fluoxetine (Prozac)FDA LinkGeneric 01/2020 - 01/2017
2	Kainic Acid (Kainate)IBA 01/2020 - 08/2008
2	Scopolamine (Hyoscine)FDA Link 01/2020 - 01/2017
2	serotonin 7 receptorIBA 01/2019 - 01/2019
2	Neurotransmitter Agents (Neurotransmitter)IBA 01/2019 - 03/2008
2	Serotonin (5 Hydroxytryptamine)IBA 01/2019 - 02/2003
2	alpha- Amino- 3- hydroxy- 5- methyl- 4- isoxazolepropionic Acid (AMPA)IBA 01/2018 - 04/2006
2	LigandsIBA 01/2016 - 06/2007
2	CurcuminIBA 06/2013 - 06/2013
2	dihydrexidineIBA 09/2011 - 05/2006
2	Aminophylline (Carine)FDA LinkGeneric 08/2008 - 07/2004
2	Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)IBA 03/2008 - 04/2007
2	Chlordiazepoxide (Elenium)FDA LinkGeneric 08/2007 - 10/2002
2	Kainic Acid Receptors (Kainate Receptor)IBA 06/2007 - 04/2006
1	brexanoloneIBA 01/2022
1	Diazepam (Valium)FDA LinkGeneric 01/2022
1	HalogensIBA 01/2022
1	BenzodiazepinesIBA 01/2022
1	Adrenergic Agents (Adrenergic Drugs)IBA 01/2020
1	Amitriptyline (Elavil)FDA LinkGeneric 01/2020
1	Tricyclic Antidepressive Agents (Tricyclic Antidepressants)IBA 01/2020
1	Muscarinic Receptors (Muscarinic Acetylcholine Receptor)IBA 01/2020
1	Cholinergic Agents (Cholinergics)IBA 01/2020
1	Dextroamphetamine (Dexedrine)FDA LinkGeneric 01/2019
1	AcidsIBA 01/2019
1	SB 269970IBA 01/2019
1	Biogenic Amines (Biogenic Amine)IBA 01/2019
1	DR-4004IBA 01/2019
1	Levodopa (L Dopa)FDA LinkGeneric 01/2018
1	Reserpine (Serpasil)FDA Link 01/2018
1	SesquiterpenesIBA 01/2018
1	Nootropic Agents (Nootropics)IBA 01/2018
1	jiadifenolideIBA 01/2018

Therapy/Procedure

8	Therapeutics 01/2022 - 04/2007
3	Ligation 01/2019 - 12/2016